The percentage of patients demonstrating a partial (greater than 50% decrease in tumor volume in 3 dimensions) or complete response on MRI in patients with high-grade gliomas treated with mebendazole in combination with bevacizumab and irinotecan, after surgical resection, to the extent feasible and local irradiation. 1999 Jun;93(4):357-65. Treatment must start within 14 days of study enrollment. 2005 Jun 15;18(6A):E7. Patients who have failed prior chemotherapy with vincristine, carboplatin, or temozolomide for this tumor are excluded. When you enter three or more characters, a list of up to 10 suggestions will popup under the textbox. N Engl J Med. J Neurosurg. All trials on the list are supported by NCI. Low-grade gliomas are often able to be treated by observation alone if they receive a total surgical resection. The study will be amended for the maximally tolerated dose for each group to be used in the remainder of the study. Brand Names: Canada. Gil-Grande LA, Boixeda D, Garcia-Hoz F, Barcena R, Lledo A, Suarez E, Pascasio JM, Moreira V. Treatment of liver hydatid disease with mebendazole: a prospective study of thirteen cases. Patients who have known allergy to mebendazole or benzimidazole class drugs. The toxicity of 5-FU is a serious and common problem for many cancer patients mainly due to myelosuppression and gastrointestinal toxicity being the most commonly observed side effects (Saif et al., 2009). 1993 Jun 17;328(24):1725-31. Ceppa EP, Bouffet E, Griebel R, Robinson C, Tihan T. The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity. Males and females of reproductive potential may not participate unless they agree to use an effective contraceptive method and continue to do so for at least 6 months after the completion of therapy.  (Clinical Trial), A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas, Experimental: High-grade Glioma/Pontine Glioma, Cohen Children's Medical Center of New York, New Hyde Park, New York, United States, 11040, Contact: Mark P Atlas, MD    718-470-3460, Contact: Derek R Hanson, MD    551-996-5437, Julie Krystal, Head, Developmental Therapeutics, Northwell Health, Maximally tolerated dose of mebendazole in combination with vincristine, carboplatin, and temozolomide [ Time Frame: Assessed after the 10 week Induction cycle ], Maximally tolerated dose of mebendazole in combination with bevacizumab and irinotecan. This is a study to determine the safety and efficacy of the drug, mebendazole, when used in combination with standard chemotherapy drugs for the treatment of pediatric brain tumors. Pilomyxoid astrocytoma: diagnosis, prognosis, and management. Patients currently on study will continue with maintenance therapy. Patients who are taking metronidazole and cannot be safely moved to a different antibiotic greater than 7 days prior to starting mebendazole therapy. Paraskevopoulos D, Patsalas I, Karkavelas G, Foroglou N, Magras I, Selviaridis P. Pilomyxoid astrocytoma of the cervical spinal cord in a child with rapid progression into glioblastoma: case report and literature review. 1988 Aug;69(2):171-6. Clinical trials look at new ways to prevent, detect, or treat disease. Int J Radiat Oncol Biol Phys. Recently, it was discovered that mebendazole may be effective in treating cancer as well, in particular brain tumors. Mebendazole is an old drug with well‐established pharmacokinetic parameters. After determination of maximally tolerated dose for each group, the study will continue to evaluate efficacy of this regimen. The primary end point is to determine the maximum tolerated dose of MBZ with temozolomide. There are numerous reasons for the interest in these medications. Mebendazole will be prescribed according to the particular dose cohort for each patient (50 mg/kg/day, 100 mg/kg/day, or 200 mg/kg/day). 2009 Nov;24(11):1397-408. doi: 10.1177/0883073809342005. Survival benefit in 2 preclinical models of glioblastoma multiforme for pediatric patients with high-grade gliomas or intrinsic! Please remove one or more characters, a list of up to 10 suggestions will popup under textbox... Irinotecan for this tumor are excluded tumors which diffusely involve the thalamus or cervical! Astrocytomas with monomorphous pilomyxoid features and a less favorable outcome cerebellar astrocytomas children! 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