2012 Aug;50(6):654-7. Respiratory and immunological reactions among Shiitake (Lentinus edodes) mushroom workers. 2015 May;13(5):455-6. [Intrapleural treatment of breast cancer patients with pleural effusions: an analysis of 13 institutes in Kyoto and Shiga Prefectures. Shimizu, Y., Hasumi, K., Chen, J. T., Hirai, Y., Nakayama, K., Teshima, H., Hamada, T., Fujimoto, I., Yamauchi, K., and Masubuchi, K. [Successful treatment of a patient with recurrent ovarian cancer by lentinan combined with intraarterial 5FU]. 2014 Oct;27(5):871-4. Food Rev.Int. Kosaka A, Kuzuoka M, Yamafuji K, et al. Akimoto, M., Nishihira, T., and Kasai, M. [Modulation of the anti-tumor effect of BRM under various nutritional or endocrine conditions]. Lentinan potentiates immunity and prolongs the survival time of some patients. View abstract. View abstract. Antiviral Effects of Shiitake. 2015 Mar-Apr;90(2):276-8. 2002;66(5):1052-1056. Use of this web site constitutes acceptance of the LIVESTRONG.COM Mushrooms are well known for their health benefits but on the other hand, it has some side effects also when consumed in excess or not fresh. View abstract. [Antimicrobial action of Lentinus edodes juice on human microflora]. The American Cancer Society notes that shiitake mushrooms are generally considered safe, although they may cause digestive distress, including bloating and diarrhea. [Randomized study of lentinan on patients with advanced gastric and colorectal cancer. Nippon Geka Gakkai Zasshi 1991;92(1):5-11. Zhang, P. and Cheung, P. C. Evaluation of sulfated Lentinus edodes alpha-(1-->3)-D-glucan as a potential antitumor agent. Gan To Kagaku Ryoho 2000;27(2):281-284. Dermatol Online J. The first signs appear 24 hours upon consumption and may be worsened by sun exposure. There are some side effects that are associated with shiitake mushrooms, including gastrointestinal distress, a worsening of autoimmune disease, sensitivity to the sun and allergic reactions. Yoshino, S., Oka, M., Hazama, S., and Suzuki, T. [Effect of intrapleural and/or intraperitoneal lentinan therapy on carcinomatous pleuritis and peritonitis with special reference to immunological evaluation]. View abstract. Intern Med 1992;31:1204-6. Tohoku Lentinan Study Group]. That’s what Siberians call them. View abstract. Chem Pharm Bull. any of the products or services that are advertised on the web site. Ishibashi, H., Hirakawa, K., Nakajima, H., Ioka, J., Shirono, K., Tanabe, S., Ochiai, K., Tomita, K., and Kitagawa, Y. View abstract. According to a study published in the "Journal of Allergy and Clinical Immunology," daily ingestion of 4 g of shiitake mushrooms over the course of 10 weeks caused blood eosinophilia. Gan To Kagaku Ryoho 1988;15(6):1973-1977. Other digestive side effects include upset stomach, nausea, persistent stomach cramps, and vomiting. Takahashi, T., Hori, Y., Isogawa, S., Saho, M., Yoshida, H., Yokoyama, K., Watanabe, M., and Nakagawa, S. [A case of hepatocellular carcinoma in an elderly patient that improved upon combination therapy of Lentinan and Tegafur]. 1996;5(1):23-28. C haga is quite safe on side effects. Another mental mushroom-related benefit: Researchers at the … Lobanok, A. G., Babitskaia, V. G., Plenina, L. V., Puchkova, T. A., and Osadchaia, O. V. [Composition and biological activity of submerged mycelium of the xylotrophic basidiomycete Lentinus edodes]. Kunitomo, K., Kawahito, M., Miura, M., and Komi, N. [Combination therapy with lentinan, mitomycin c, 5-fluorouracil and radiation--a case of long-term survival of pancreas cancer after palliative surgery]. Little is known about the safety of long-term use of AHCC. Int J Cancer 3-15-1980;25(3):371-376. Yakugaku Zasshi 1996;116:169-73. Matsuoka H, Seo Y, Wakasugi H, et al. Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC. Gan To Kagaku Ryoho 1986;13(4 Pt 2):1270-1276. View abstract. 2013 Dec;52(12):1620-1. Sastre, J., Ibanez, M. D., Lopez, M., and Lehrer, S. B. Med.Microbiol.Immunol. Contact Dermatitis 1992;27:65-70. View abstract. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Nippon Gan Chiryo Gakkai Shi 3-20-1989;24(3):647-651. Int J Occup Med Environ Health. Information from this source is evidence-based and objective, and without commercial influence. [10] Eosinophilic oesophagitis developed after intake of shiitake mushroom … Wong, G. Y. C., Katdarae, M., Osborne, M. P., and Telang, N. T. Preventative efficacy of Lentinus edodes mycelium extract (LEM) in human mammary carcinogenesis (abstract 321). Lentinan is used by … 1998;18(11):665-667. Clin Exp Dermatol. These side effects are often when the mushrooms are consumed in large amounts but people with a sensitive stomach or multiple food allergies should eat these mushrooms with caution. View abstract. View abstract. View abstract. However, there's some concern that AHCC may trigger mild side effects, including bloating, diarrhea, itching, foot cramps, and fatigue.6 There have also been reports of feeling feverish or elevated body temperature after daily use of AHCC. Br.J Dermatol. Contact Dermatitis 1992;26:228-33. Side Effects of Shiitake Mushroom. Copyright © Destroy Cancer Cells. 2005;(1):80-82. Gu, Y. H. and Belury, M. A. View abstract. [A case of chronic hypersensitivity pneumonitis induced by shiitake mushroom spores]. Fujiwara, K., Sato, T., Yonei, T., Genba, K., Nogami, N., and Yamadori, I. View abstract. They are parasitic fungi that target mostly birch trees. Yamada, T., Watanabe, A., Sadou, S., Nishinuma, T., Tsurui, H., Watanabe, T., and Nakano, H. [A case of advanced gastric cancer with hepatic metastasis successfully treated by combined chemotherapy with UFT and lentinan]. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse Hatvani, N. Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture. Shiitake can be eaten fresh or dried and pressed into tablets or capsules. View abstract. View abstract. Gan To Kagaku Ryoho 1990;17(8 Pt 2):1588-1591. Gan To Kagaku Ryoho 1985;12(2):366-378. Side Effects The most common side effect that usually occurs from consuming raw or undercooked shiitake is “shiitake dermatitis” — a characteristic skin irritation sometimes followed by fever and digestive issues [ 67, 68, 69 ]. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Mushrooms are delicious in taste, easy to cook, and also do not adds up to the harmful side effects. A study reported that handling or consuming raw shiitake mushrooms can lead to a skin rash called shiitake mushroom dermatitis, which is likely caused by polysaccharide lentinan [16] . Mio, H. and Terabe, K. [Postoperative immunochemotherapy for gastric carcinoma with peritoneal dissemination--the effects with the combination of CDDP, 5-FU and lentinan]. Czarnecka AB, Kreft B, Marsch WCh. View abstract. View abstract. Murakami M, Kawabe K, Hosoi Y, et al. Tooth plaque. Mendonça CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. 2015 Apr;40(3):332-3. Nishihira T, Akimoto M, Mori S. [Anti-cancer effects of BRMs associated with nutrition in cancer patients]. View abstract. Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). The American Cancer Society notes that shiitake mushrooms are generally considered safe, although they may cause digestive distress, including bloating and diarrhea. Clin Exp Dermatol. Shiitake mushrooms can be included in your daily diet but only in regulated amounts. View abstract. Cancer Lett 3-18-2005;220(1):21-28. It can cause stomach discomfort, blood abnormalities, and skin swelling (inflammation). The material appearing on LIVESTRONG.COM is for educational use only. 2009 Dec;34(8):e910-3. Cancer Immunol.Immunother. It is possible that lion’s mane mushrooms might boost cognitive function, but the … It also has many beneficial vitamins and minerals.This mushroom contains Lentinan. Int J Dermatol. Scientists haven’t yet tested shiitake mushrooms against the new coronavirus (SARS-CoV-2 or COVID-19). 2005;5(5):811-820. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. View abstract. Takita, M., Onda, M., Tokunaga, A., Shirakawa, T., Ikeda, K., Hiramoto, Y., Teramoto, T., Oguri, T., Fujita, I., Okuda, T., Mizutani, T., Kiyama, T., Yoshiyuki, T., and Matsukura, N. [Successful treatment of hepatic metastasis of gastric cancer with 5'-DFUR and Lentinan]. 1996;16(4):224-226. Shiitake is used as an anti-cancer drug in Japan and sanctioned for this purpose by their FDA.It has many health benefits, such as it’s ability to lower blood pressure and reduce cholesterol. But, anything that is proven to be beneficial is also limited to some extent and the same principle applies to mushrooms as well. Shiitake mushroom is LIKELY SAFE when consumed by mouth in food amounts, but it seems POSSIBLY UNSAFE to take by mouth in medicinal amounts. What factors influenced or will influence your purchase? 2014 Jul;52(6):625-8. View abstract. Shiitake dermatitis with oral ulceration and pustules. View abstract. View abstract. View abstract. Lippert, U., Martin, V., Schwertfeger, C., Junghans, V., Ellinghaus, B., and Fuchs, T. Shiitake dermatitis. View abstract. Arinaga S, Karimine N, Takamuku K, et al. View abstract. J Biomed Biotechnol. Hinyokika Kiyo 1994;40:119-23. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 1993;13(5C):1773-1776. It is a whole food. Int.J.Immunopharmacol. We currently have no information for SHIITAKE MUSHROOM Interactions. Effects of oral lentinan on T-cell subsets in peripheral venous blood. View abstract. Cutis. View abstract. View abstract. Nowadays mushrooms are known as superfoods because of high nutrients and protein content. View abstract. 1995;11:111-128. Gastroenterol Rep (Oxf) 2019;7(4):298-300. doi: 10.1093/gastro/gox028. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. J Gastroenterol 1998;33:562-5. Gan To Kagaku Ryoho 1990;17(8 Pt 1):1517-1519. Shiitake mushroom dermatitis. View abstract. Gan To Kagaku Ryoho 1994;21:2323-5. Gan To Kagaku Ryoho 2003;30(9):1289-1296. Precautions and Side Effects: Shiitake mushroom has been used safely by millions of people of all ages throughout the world for centuries. 1993;15(6):751-756. A phase II controlled study of a combination of the immune modulator, lentinan, with didanosine (ddI) in HIV patients with CD4 cells of Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. View abstract. View abstract. View abstract. 2015 Jul;29(7):1449-51. Wada T, Nishide T, Hatayama K, et al. Mushroom Side Effects: The Things You Should Care Mushrooms are consumed globally because of their many promising benefits for varieties of health conditions. View abstract. View abstract. View abstract. View abstract. Prostate cancer. View abstract. J Allergy Clin Immunol 1998;101:613-20. Ade R, Sukut C, Wiser HJ, Shockman S, Buescher L. Shiitake dermatitis demonstrating Köebner phenomenon. Gan To Kagaku Ryoho 1986;13(4 Pt 1):1050-1059. Some of the shiitake mushroom side effects are as follows. [A comparative clinical trial with tegafur plus lentinan treatment at two different doses in advanced cancer]. Gan To Kagaku Ryoho 2000;27(1):107-111. What are the side effects of shiitake mushrooms? Shiitake may cause some side effects, such as skin rashes. Flagellate shiitake mushroom dermatitis. J Med 1998;29:305-30. Jpn.J.Cancer Res. Nutrients 2019;11(11):2720. doi: 10.3390/nu11112720. View abstract. View abstract. Wang AS, Barr KL, Jagdeo J. Shiitake mushroom-induced flagellate erythema: A striking case and review of the literature. Two cases of small bowel obstruction due To handling or eating a raw.... N'T miss shiitake dermatitis: a phase I/II trial lentinan shiitake mushroom side effects patients with pleural effusions: an analysis 13... 27 ( 1 ):107-111 24 hours upon consumption and may be in... Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma ] UFT and lentinan.... [ studies on the effect of lentinan with combined use ] ( 12 ).... 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