a) True b) False 7. SERPENTINA: The Herb For Diabetes, Liver, Heart Disease, Kidney, Colds And Flu, How to lower your A1C levels: A healthful guide, Diabetes Experts Share Ways To Lower Your A1C Levels, How to Lower Your A1C Levels: More Steps You Can Take, 12 Silent Diabetes Complications You Need to Know About—and How to Avoid Them, How Low Can You Go? VIKAS AGGARWAL, MD 1 ANDREA L.C. People who are anemic have short-lived red blood cells, so like diabetics, they will test with falsely low A1c levels. Hemoglobin A1c (HbA1c) is used in diabetic patients as an index of glycemic control reflecting glucose levels of the previous 3 months. Our patient was homozygous for hemoglobin SS (sickle-cell disease) with 59.8% hemoglobin S on her electrophoresis. The level is used in the screening, diagnosis and management of diabetes mellitus. The remainder of her screening tests were normal. Persistently high sugar levels can damage the small blood vessels in the body. The population … Red blood cells live for around 4 months, so A1C results reflect long-term blood glucose levels. Continue reading >>, This week, the British Journal of Cancer published an incredibly important report that found a strong relationship between a simple blood test and the risk for various forms of cancer. People with diseases affecting hemoglobin, such as anemia, may get misleading results with this test. But with this new report, we now understand that having elevated A1c translates to risk for cancer, and as I’ve explained in Grain Brain, it is also a powerful indicator of risk for developing dementia. RESEARCH DESIGN AND METHODS Prospective cohort study of 13,288 participants in the Atherosclerosis Risk in Communities Study. Did you keep going or decide to go up a few points to feel safer? This is vital, since too-high or too-lo In the case of our patient, her hemoglobin electrophoresis demonstrated 0% hemoglobin A, which explains her A1c value of <3.5%. When glucose enters the blood, it binds to a red blood cell protein called hemoglobin. In diabetes mellitus, higher amounts of glycated hemoglobin, indicating poorer control of blood glucose levels, have been associated with cardiovascular disease, nephropathy, neuropathy, and retinopathy. Glycosylated (or glycated) hemoglobin (hemoglobin A1c, Hb1c , HbA1c, or A1C; sometimes also HgA1c) is a form of hemoglobin used primarily to identify the average plasma glucose concentration over prolonged periods of time. Glycohemoglobin (hemoglobin A1c) is a form of hemoglobin that is bound to glucose. A number of clinical syndromes may impact the accuracy of this laboratory value. Given the microcytosis noted on the complete blood count (CBC) and elevated rate of hemoglobinopathies in this patient's ethnic group, a hemoglobin electrophoresis was performed and was markedly abnormal: 0% hemoglobin A, 36.3% hemoglobin F, 3.9% hemoglobin A2, and 59.8% hemoglobin S. The interpretation of this electrophoresis was homozygosity of hemoglobin S (sickle-cell disease) in combination with hereditary persistence of fetal hemoglobin. a) True b) False *NO TITLE Created by the National Diabetes Education Program *JAVASCRIPT var numQuestions=10; ans[1] = "true"; ans[2] = "true"; ans[3] = "true"; ans[4] = "true"; ans[5] = "false"; ans[6] = "false"; ans[7] = "true"; ans[8] = "true"; ans[9] = "false"; ans[10] = "false"; explainAnswer[1]="The hemoglobin A1c test shows the average amount of sugar in your blood over the last 3 months. And if 6.0% is close to a functioning pancreas percentage, then what’s the problem? Logistic regression was used to identify cross-sectional correlates of low HbA1c, and Cox proportional hazards models were used to estimate the association of low HbA1c with cause-specific mortality. Patients with pre-existing diabetes: DM patient have short-live red blood cells, which in turn lead to false low hemoglobin A1c results. 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